Education: Ph.D., National Taiwan University, Taiwan
My research is motivated by a desire to answer one of the fundamental questions in evolutionary biology – the genetic changes that underlie phenotypic differences between closely related species. Both genetic and phenotypic changes between closely related species have been well documented. Yet, the connection between the two is little known. One way to unveil the genetic changes accumulated during species differentiation is to study the genetics of individual traits that contribute to any form of reproductive isolation, such as habitat shift, premating isolation, etc., between closely related species. The main goal of my research is to bridge genotypic and phenotypic changes that occur during species divergence by means of genetic approaches.
Li J, Jiang L, Wu CI, Lu X*, Fang S*, and Ting CT*. (2019) Small segmental duplications in Drosophila—High rate of emergence and elimination. Genome Biol Evol 11: 486–496.
Chen, C K, Yu CP, Li SC, Wu SM, Lu MJ, Chen JH, Chen RD, Ng SC, Ting CT*, and Li WH*. (2017) Identification and evolutionary analysis of long non-coding RNAs in zebra finch. BMC Genomics 18: 117.
Chen CK, Ng CS, Wu SM, Chen JJ, Cheng PL, Wu P, Lu MJ, Chen DR, Chuong CM, Cheng HC*, Ting CT* and Li WH*. (2016) Regulatory differences in natal down development between altricial zebra finch and precocial chicken. Mol Biol Evol 33: 2030–2043
Yang H, He B, Ma H, Tsaur SC, Ma C, Wu Y, Ting CT, Zhang YE*. (2015) Expression profile and gene age jointly shaped the genome-wide distribution of premature termination codons in Drosophila populations. Mol Biol Evol 32: 216-28
Chang C‡, Ting CT‡, Chang CH, Fang S, Chang H. (2014) The persistence of facultative parthenogenesis in Drosophila albomicans. PLoS One 9: e113275. (‡equal contribution)
Hungate EA, Earley EJ, Boussy IA, Turissini DA, Ting CT, Moran RJ, Wu ML, Wu CI, and Jones CD*. (2013) A locus in Drosophila sechellia affecting tolerance of a host plant toxin. Genetics 195:1063-1075.
Poh YP*, Ting CT, Begun DJ, and Langley CH. (2012) Population genomic analysis of base composition evolution in Drosophila melanogaster. Genome Biol and Evol 4: 1245-1255.
Cheng YJ, Fang S, Tsaur SC, Chen YL, Fu HW, Patel NH, and Ting CT*. (2012) Reduction of germ cells in the Odysseus null mutant causes male fertility defect in Drosophila melanogaster. Gene Genet Syst 87: 273-276.
Lu X, Shapiro JA, Ting C-T, Li Y, Li C, Xu J, Huang H, Cheng, YJ, Greenberg AJ, Li SH, Wu ML, Shen Y, Wu CI.(2010) Genome-wide misexpression of X-linked versus autosomal genes associated with hybrid male sterility. Genome Research 20: 1097-1102.
Fang S, Ting CT, Lee CR, Chu KH, Wang CC, Tsaur SC. (2009) Molecular evolution and functional diversification of fatty acid desaturases after recurrent gene duplication in Drosophila. Molecular Biology and Evolution, 26: 1447-1456.
Sun S, Ting CT, Wu CI.(2004) The normal function of a speciation gene, Odysseus, and its hybrid sterility effect. Science 305: 81-83.
Wu CI, Ting CT.(2004) Genes and speciation. Nature Reviews Genetics, 5: 114-122. Ting CT, Tsaur SC, Sun S, Browne WE, Chen YC, Patel NH, Wu CI.(2004) Gene duplication and speciation in Drosophila: Evidence from the Odysseus locus. Proceedings of the National Academy of Sciences USA 101: 12232-12235.
Takahashi A, Ting CT.(2004) Genetic basis of sexual isolation in Drosophila melanogaster. Genetica, 120: 273-284.
Ting CT, Takahashi A, Wu CI.(2001) Incipient speciation by sexual isolation in Drosophila: Concurrent evolution at multiple loci. Proceedings of the National Academy of Sciences USA, 98: 6709-6713.
Tsaur SC, Ting CT, Wu CI.(2001) Sex in Drosophila mauritiana: A very high level of amino acid polymorphism in a male reproductive protein gene, Acp26Aa. Molecular Biology and Evolution, 18: 22-26.
Ting CT, Tsaur SC, Wu CI.(2000) The phylogeny of closely related species as revealed by the genealogy of a speciation gene, Odysseus. Proceedings of the National Academy of Sciences USA, 97: 5313-5316.
Ting CT, Tsaur SC., Wu ML, Wu CI.(1998) A rapidly evolving homeobox at the site of a hybrid sterility gene. Science, 282: 1501-1504.
Tsaur SC, Ting CT, Wu CI.(1998) Positive selection driving the evolution of a gene of male reproduction, Acp26Aa, of Drosophila: II. Divergence versus polymorphism. Molecular Biology and Evolution, 15: 1040-1046.
Hollocher H., Ting CT, Wu ML., Wu, C.-I.(1997) Incipient speciation by sexual isolation in Drosophila melanogaster: Extensive genetic divergence without reinforcement. Genetics, 147: 1191-1201.
Hollocher, H., Ting, C.-T., Pollack, F., Wu, C.-I.(1997) Incipient speciation by sexual isolation in Drosophila melanogaster: Variation in mating preference and correlation between sexes. Evolution, 51: 1175-1181.
Chang H, Ting CT, Lin FJ, (1994) On the low genetic variability in Drosophila immigrans and D. formosana., Zoological Studies, 33: 287-295.